Hashimoto's thyroiditis pathogenesis pdf

The autoimmune chronic thyroiditis or hashimotos thyroiditis ht is an. It is an autoimmune condition that causes inflammation of. Hashimotos thyroiditis is also known as chronic lymphocytic thyroiditis or autoimmune thyroiditis. The green arrow points to healthy thyroid gland cells, the orange arrow points to dark purple cells. Similar histopathological features have often been noted in the fibrous variant of hashimotos autoimmune thyroiditis, but thyroid gland involvement has been only briefly mentioned with regard to. This pdf is well known record in the world, of course many people will attempt to own. Also called hashimotos disease, hashimotos thyroiditis is an autoimmune disease, a disorder in which the immune system turns against the bodys own tissues. It is an autoimmune disorder involving chronic inflammation of the thyroid. Hashimotos thyroiditis ht is an autoimmune disorder characterized by diffuse thyroid lymphocytic infiltration and follicle destruction.

But till now it is still enigmatic disease with not so well known causes and etiology. The pathogenesis of hashimotos thyroiditis researchgate. Hashimotos thyroiditis ultrasound image of thyroid gland, exam was done for suspicion of nodules on the gland, us revealed diffuse hashimotos with no presence of nodules2 this is a picture of a patient with hashimotos. The term thyroiditis refers to inflammation of the thyroid gland. Hashimotos thyroiditis american thyroid association. If hashimoto s thyroiditis causes cell damage leading to low thyroid hormone levels, patients will eventually develop symptoms of hypothyroidism see hypothyroidism brochure. At the base of the pathology there is an inflammatory. In this condition, immune cells produce antibodies against a key enzyme that is required for thyroid hormone production thyroid peroxidase andor against thyroglobulin, which is the building block of thyroid hormones. Adults present with painless, gradual thyroid failure due to autoimmune destruction, may initially have transient hyperthyroidism. Autoimmune hashimotos thyroiditis, the most common endocrine dis order, is primarily a subclinical disease.

Hashimotos thyroiditis chronic autoimmune thyroiditis is the most common cause of hypothyroidism in iodinesufficient areas of the world. Risk factors and pathogenesis of hashimotos thyroiditis. Further developments in our understanding indicates that ht is likely to be an extreme in this distribution and does not constitute a separate disease entity, although there are different clinical presentations across the distribution curve 3. The etiology of hashimotos thyroiditis is considered to be multifactorial, involving the. Hashimotos thyroiditis lifestyles interventions for. Hashimoto s thyroiditis, also known as chronic lymphocytic thyroiditis, is the most common cause of hypothyroidism in the united states. Novel developments in the pathogenesis and diagnosis of. Hashimotos thyroiditis ht and graves disease gd are two very common organspecific autoimmune diseases which are characterized by circulating. The development of lymphoid tissue directly in the thyroid gland with progressive destruction of the thyroid cells, eventually leads to hypothyroidism 58. Risk factors, pathogenesis, signs and symptoms and treatment.